
Комбинированная терапия

The Cyprus Protocol – Multimodal Combination Therapy for Long COVID, Post-Vac and Chronic Illnesses
In the field of HIV and cancer, combination therapy is one of the most successful forms of treatment – often it is the gold standard in the specific field.
Вместе с участниками по всему миру и благодаря нашему клиническому опыту в сочетании с исследованиями, проводимыми под руководством пациентов, мы разработали первый мультимодальный протокол комбинированной терапии для длительного COVID, синдрома после отпуска и хронических заболеваний.
We named it after it’s place of origin:
'Кипрский протокол'
Below you find a dynamic list of the protocol’s elements and a treatment schedule example.
Заболевания, которые мы лечим

Какие заболевания мы лечим в Центре афереза по Кипрскому протоколу?
Вот несколько примеров (не ограничиваясь ими) наиболее распространенных заболеваний, которые мы лечим в нашей клинике:
- Лонг Ковид (PCS)
- Пост-вакцинация (PVS)
- Пост-инфекционные/пост-вирусные синдромы
- POTS
- ЭЦП
- MCAS / IBS / SIBO
- PANS / PANDAS
- PIMS / MIS-C
- Аутоиммунные заболевания
- Сидром хронической усталости
- Реактивированные заболевания (EBV, Mono, CMV, Herpes, Babesia, Bartonella)
- Болезнь Лайма
- Фибромиалгия
- ME/CFS
- Рассеянный склероз
- Волчанка
- Ревматоидный артрит
- Синдром Сьёгрена
- Raynaud’s Disease
- Склеродермия
- Альцгеймер
- Паркинсон
- СФН / Нейропатия
- MCS
- Другие заболевания с воспалительными, аутоиммунными и микроциркуляторными проблемами, а также заболевания, в основе которых лежат токсины или патогенные микроорганизмы
Элементы Кипрского протокола
Нажмите на каждый элемент Кипрского протокола, чтобы получить более подробную информацию
Для каждого пациента протокол должен быть индивидуальным.
With the new diagnostic tools of our D-T-R model – Continous Diagnostics we are now able to apply targeted treatments with higher precision.
Independent of the treatment a patient is undergoing – without adapted nutrition for the three treatment phases pre-treatment, on-treatment and post-treatment, the achievable results differ.
This is why we base our Combination Therapy on individual and personalized nutrition plans for every patient, based on the results of blood panel test and food intolerance test that show IgG reactions to 287 foods (vegetables, fish & seafood, fruits, spices, nuts, legumes, meat, egg & milk, cereals & seeds, nuts, coffee & tea and novel foods).
Our Clinical Nutritionist Chryso Zorbas will hold your hand nutritionally from day one and guide you along the therapy with a personalized diet plan that will enhance your recovery process. Needless to say that our Health Coaching (see below) is a perfect match and goes hand in hand with our Clinical Nutrition Supervision.
Learn more about Clinical Nutrition Supervision here
Chronic Illness is very complex – having an expert patient turned professional Health Coach by your side throughout your whole journey offers priceless knowlege and guidance.
Our Health Coach Tanja Walser will coach you from day one and guide you along the therapy with a personalized coaching plan that will include all the dos and don’ts and give you a headstart despite brainfog, anxiety or other symptoms you are battling with.
Learn more about Health Coaching here
Our most effective treatments to date: At the core of our multimodal Combination Therapy are several forms of Therapeutic Apheresis’ – special blood purifications by precipitation/adsorption/filtration procedures. They serve to treat microcirculation / blood flow issues (microclots are removed, blood flow increased) and removes pathogenic or disease-sustaining proteins as well as protein-bound substances and autoantibodies from the blood. Amongst other substances environmental toxins, inflammation proteins, viral spike protein, cholesterol + autoantibodies are removed
Learn more about H.E.L.P. Apheresis
Learn more about Inuspheresis®
Learn more about Immunoadsorption
In some cases H.E.L.P. Apheresis will be combined with TPPE – Therapeutic Partial Plasma Exchange
Система гипертермии всего тела Heckel HT3000 позволяет целенаправленно повышать температуру тела, от легкой до высокой. Гипертермия всего тела не только устраняет симптомы, но и направлена на восстановление улучшенного регуляторного контроля во всем организме. Системы гипертермии всего тела Heckel - это значимый вклад в лечение широкого спектра заболеваний и состояний - от укрепления здоровья до облегчения боли и поддерживающей терапии при хронических заболеваниях и раке. В системах Long Covid и Post Vac дополнительными желаемыми эффектами являются освобождение рецепторов и разрушение патогенных белков.
Long Covid and many other Chronic Illnesses are at their root an endothelitis/vasculitis with severe inflammation, combined with hypercoagulation and often viral persistence. Autoimmunity components can be involved too.
IV treatments work directly where needed the most: in the blood vessels in the desired concentration.
IV/Intravenous therapies that are used in our Long COVID and Chronic Illnesses Combination Therapy are:
– IV Vitamin C (Reducing inflammation)
– IV Glutathione (Antioxidant)
– IV Multivitamin Protocol (Balancing deficiencies)
– IV NAD+ (Metabolism/mitochondria benefits)
– IV Alpha Lipoic Acid (Metabolism/nerve pain reduction)
– IV Zinc (Reducing inflammation, speeding up recovery)
– IV Magnesium (Electrolyte reducing fatigue and anxiety)
– IV NAC (Reduces brainfog/relieves respiratory discomfort)
– IV Taurin (Is Cytoprotective (cell protective) and detoxyfying)
– IV Arginine (Increases elasticity of blood vessels and increases blood flow)
– IV Lysine (Increases cell healing and wound healing)
– Other IVs: Iron, Selenium, Amino Acids, Minerals and more
Peptide Therapy:
Peptide therapy offers a groundbreaking approach to restoring balance and vitality for individuals struggling with long COVID, post-vaccine syndrome, and chronic illnesses. Peptides are short chains of amino acids that act as signaling molecules in the body, promoting tissue repair, immune modulation, and cellular rejuvenation. By targeting underlying dysfunctions such as inflammation, impaired immunity, and mitochondrial damage, peptide therapy can accelerate recovery, enhance energy, and support overall wellness. Tailored to each patient’s unique needs, this therapy provides a safe and effective way to improve quality of life, fostering the body’s natural ability to heal and thrive.
Find more information on our IV Therapy and Peptide Therapy click here for iv therapy and peptide therapy
Chelation Therapy:
Chelation therapy is a medical intervention characterized by the administration of chelating agents, substances with a high affinity for certain metal ions, to facilitate the removal of heavy metals and minerals from the body.
Find more information on Chelation Therapy here
Our Nutraceutical treatment strategy for the detoxification from viral spike protein involves the following 4-step process:
The first step is preventing reinfection by blocking the receptors on host cells, which the virus and viral spike protein use to gain entry.
The second step is to help restore autophagy processes, which are the body’s natural way of cleaning out damaged cells and regenerating new ones.
The third step aids in liberating viruses and viral spike proteins by selectively targeting infected or transfected cells.
The fourth step facilitates the sequestration of viral spike protein and virus, effectively removing them. The most efficient way to do this is H.E.L.P. Apheresis and where that is not possible, the use of Algerol is indicated.
This comprehensive approach aims to remove the spike protein from the body safely while also enhancing the immune system’s ability to prevent further infections.
At the end of our therapy course we add a 3-6 months NAC Augmented protocol.
Find more about Nutraceutical Therapy here
Medication and supplement protocols increase H.E.L.P. Apheresis results further and can be used to treat patients symptom-specific. The protocols include Antiviral Protocols and Anticoagulation Protocols.
Symptoms the medication protocols focus on are:
– Viral persistence
– Persisting hyper coagulation
– MCAS (mastcell activation syndrome), often combined with gastroparesis
– Endothelial damage, often combined with hypercholesterolaemia
– Neuro inflammation/brain inflammation
– Fatigue, PEM often combined with mitochondrial dysfunction
– Insomnia
– Induced anxiety/paranoia/depression
– Reactivated viruses
– Others
Find more information on Antiviral Therapy and Anticoagulation Therapy
Anxiety, Depression, PTSD, Chronic Pain and Fatigue Therapy for Long Covid and Chronic Illness
Are you or a loved one struggling with the lingering effects of Long Covid or battling the relentless challenges of chronic illness? At the Apheresis Center we understand the toll these conditions can take on both your physical and mental well-being. That’s why we offer revolutionary approaches to treatment.
Find more about Depression & Anxiety Therapy here
Colon Hydrotherapy, also known as colonic irrigation, constitutes an internal cleansing procedure designed to rid the colon of deleterious waste materials. This therapeutic intervention serves as a rapid and highly efficient means of detoxification for the body. The mild internal hydration expeditiously eliminates pathogenic toxins by leveraging the natural peristaltic movements, further facilitated by abdominal massage. Notably, this process has implications for individuals with symptoms that present similar to Mast Cell Activation Syndrome (MCAS), as it influence the systemic responses associated with this symptoms often triggered by Long Covid, Post Vac or other Chronic Illnesses.
Our Medical Team has designed a MCAS treatment package which is tailored to each patient individually
MCAS Blood Test (CCL2, IL-6, IL-8, IL-31, IL-33, TNF-alpha, Tryptase)
Nutrition Plan
3x Colon Hydrotherapy, ozonated treatment
3x Leaky Gut IV (L-Lysin, Taurin, L-Alanyl-Glutamin, Glycin, Cholinchlorid, Magnesiumchlorid, Kaliumchlorid
MCAS Medication Plan including Nutraceuticals and Nanozeolites
Find more information on Colon Hydrotherapy and MCAS Treatment here
The application of Intravenous Immunoglobulin (IVIG, if subcutaneously administered also called SCIG)) and monoclonal antibodies (mABs) like Evusheld or Xevudy (Sotrovimab) represents a new area in treating Long Covid, Post Vac and Chronic Illnesses. These conditions involve complex immune dysregulation and inflammatory responses. IVIG is a concentrated preparation of immunoglobulins derived from pooled human plasma.
Monoclonal antibodies, designed to target specific components of the immune response, present another avenue for intervention. Both IVIG and mABs are being investigated for their potential to restore immune homeostasis.
The current official indications include symptoms present in chronic illness and many post-viral conditions: Myo- and Pericarditis, Small Fiber Neuropathy but also acute/severe conditions like Sepsis.
Find more about IVIG and mABs Therapy here
For specific symptoms and subgroups after H.E.L.P. Apheresis treatment these treatments can speed up and enforce the recovery process. (Note: HBOT is only administered after H.E.L.P. Apheresis therapy. Ozone-EBOO is only administered after H.E.L.P. Apheresis and only in special cases)
Find more information on Hyperbaric Oxygen Treatment here and Cryotherapy here
Mitochondrial therapy, also known as metabolic correction, is an emerging approach in the management of Long Covid and chronic illnesses characterized by fatigue. This therapy aims to enhance mitochondrial function, which is often impaired in these conditions, by providing specific nutrients and cofactors that support cellular energy production. Key substances used in mitochondrial therapy include NAC (N-Acetyl L-Cysteine), L-Serine, L-Carnitine, Nicotinamide Riboside (NR), L-Choline, NT Factor, and NADH. These compounds work synergistically to replenish depleted cellular antioxidants, enhance mitochondrial biogenesis, improve fatty acid metabolism, and restore ATP production, ultimately helping to alleviate fatigue and improve overall cellular health in individuals suffering from prolonged symptoms of Long Covid and other chronic fatigue-related conditions.
Find more about Mitochondrial Therapy here
Many of our last year’s patients had to come back to us for another course of H.E.L.P. Apheresis and Combination Therapy treatment, because they reinfected with Covid and were thrown back to experiencing Long Covid symptoms. This is why we started giving out ‘Early Treatment packages’ which avoid exactly that. Our prescribing doctors will supply you with everything needed to get through your next reinfection without risking to worsen again.
Пример расписания лечения
Визуализация вариантов лечения по Кипрскому протоколу
In the below PDF you find a visualisation of available treatments (this is solely for the purpose of demonstrating available options – this NOT a real life case/treatment schedule)
Рекомендация: Скачайте и увеличьте изображение, чтобы узнать подробности.
Научные источники и исследования по терапевтическому аферезу при длительном ковид/пост-вакцинальном состоянии и других заболеваниях
H.E.L.P. Аферез
- Диагностика и лечение инфекционных заболеваний по Гэвину
- Researchgate
- Springer
- Frontiers
- Терапевтический аферез и диализ
- Журнал Тромбоз и гемостаз
- Springer Nature
- Американский медицинский журнал
- PubMedCentral
- Наука
A collection of sources which have published success rates can be found at the Long Covid Apheresis Community (LCA Community): https://lcacommunity.org/research
Результаты, опубликованные сообществом LCA, были подтверждены на выставке ISFA2023:
ISFA 2023 (Всемирная конференция Международного общества афереза)
Инусфериз
Science 2024 – new study looking at the relation between microclots and immune damage in Long Covid:
Quote: ‘…coagulation in Long Covid is indicated by the detection of circulating fibrinolysis-resistant microclots that are enriched in vWF, C7, acute-phase serum amyloid proteins, and fibrin, proteins identified in the proteomics screen by Cervia-Hasler et al. as contributors to Long Covid.’
Full study: https://www.science.org/doi/10.1126/science.adn1077
Проще говоря, это исследование изучает причины сохранения симптомов у некоторых людей после выздоровления от COVID-19 - состояния, известного как Long Covid. Исследователи обнаружили, что у пациентов с Long Covid продолжается активация иммунной системы, в частности системы комплемента, что приводит к воспалению и образованию тромбов. В отличие от острого COVID-19, при котором печень играет основную роль в иммунных реакциях, при Long Covid воспаление кажется более локализованным, вовлекая ткани и иммунные клетки. Авторы исследования предполагают, что эта постоянная иммунная активация, особенно в системе комплемента, способствует появлению симптомов, с которыми сталкиваются пациенты с Long Covid.
Исследователи выявили специфические белки, такие как пентраксин 3 и компоненты комплемента, которые связаны с Лонг Ковидом. Система комплемента, когда она не контролируется, может вызывать повреждение клеток и кровеносных сосудов. У пациентов с Long Covid наблюдается чрезмерная активация комплемента, что приводит к воспалению и образованию microclot . Это продолжающееся воспалительное состояние, даже при отсутствии широко распространенного свертывания крови, может объяснять сохраняющиеся симптомы, наблюдаемые при Long Covid, такие как усталость и когнитивные проблемы.
Кроме того, исследование выявило дисбаланс факторов, связанных со свертываемостью крови, что позволяет предположить потенциальный механизм тромбовоспаления при Long Covid. Хотя точные причины постоянной иммунной активации и тромбообразования при Long Covid до конца не выяснены, исследование показывает, что воздействие на определенные компоненты иммунной и свертывающей систем может стать потенциальным способом лечения Long Covid.
H.E.L.P. Apheresis and Inuspheresis® address most if not all of the above. Microclots, Hypercoagulation, Inflammation, Pathogens to list just a few modes of action of H.E.L.P. Apheresis and Inuspheresis® . The rest can be addressed by other elements of the multimodal Combination Therapy of ‘The Cyprus Protocol’.
You will find extensive information on our blog post about different types of Apheresis and which type is suitable for which purpose HERE
E-mail info@apheresiscenter.eu
Call us +357 24257400
Наш центр афереза и H.E.L.P. Аферез на телевидении
ITV News, BBC News, France 2 и WDR TV. Выдержки из некоторых репортажей о нашем Центре афереза и H.E.L.P. Аферез для лечения пост- и посткоклюшного синдрома, синдрома после отпуска и хронических заболеваний.
Отзывы
Джереми Смит, Лонг-Ковид, Соединенные Штаты Америки
‘I had 4 Help Apheresis treatments last year in Germany. They brought me back to 80% of my former capacity.
The Apheresis Center is a totally different experience and I am super happy I chose Cyprus. It is very different from Germany. The doctors, nurses and the whole team are doing everything to bring me back to my full capacity, their knowledge about Long Covid and the individually adapted treatment is great – a real concierge medicine experience! I missed home last year in Germany – here in Cyprus not a single day, we even extended our stay and will come back next year for holidays!’
You can read and watch Jeremy’s full story here: Full Video
Катрина Крулла, Лонг-Ковид, Соединенные Штаты Америки
‘I have had some amazing results with H.E.L.P. Apheresis for my Long Covid – my 6th treatment got me back to feeling 75% to 90% recovered. Larnaca was truly an amazing place for recovery. Also the great community for support that formed with others getting treatment was so wonderful. It was so nice to have a team of people helping you that “got it” and believed you in addition to being with others suffering the same life changing illness.’
Патриция Прайс, ME/CFS, Великобритания
Патриция страдает от тяжелой формы MECFS с 2015 года:
‘My Help Apheresis treatment improved my ME by 80%. Help Apheresis took me from being mostly bed bound 23 hours a day – I could not be upright without my heart jumping to 170 beats per minute, even higher if I tried to have a shower – to being able to be upright and be mobile almost every day. It changed my life! I can now manage my own life again. I can go outside again and I was able to gain weight and can now eat three solid meals a day again!
You can watch Patricia’s full story here: Full Video
Ланден Уильямс, Лонг-Ковид, США
Ланден испытывал проблемы с дыханием, беспокойство, туман в мозгу и другие симптомы до того, как мы начали лечить его с помощью H.E.L.P. Apheresis. Спустя несколько месяцев после лечения он вернулся на 70 % к прежнему состоянию, некоторые симптомы усталости и ПЭМ частично сохраняются. Он борется с ними с помощью комбинированной терапии. Приведенное выше видео - это краткая версия/выдержка из его выступления на 1819 News (Источник: 1819news)
Combination Therapy and H.E.L.P. Apheresis do not achieve the same results in the same time frame for different patients. From our clinical experience we have seen similar success rates as presented on the ISFA 2023 (World Conference of the International Society for Apheresis) – 80% success rate with results varying from smaller improvements to being fully curative. The majority of patients saw a significant improvement. Long Covid, Post Vac and CI are umbrella terms with different subsets – no patient presents the exact same symptoms set.
The time frame in which patients see results also vastly differs – from first treatment to several months.
Документальный фильм телеканала ARTE "Long Covid - исцеление на Кипре
Документальный фильм телеканала ARTE "Long Covid - исцеление на Кипре" о нашем центре афереза
Документальный фильм вышел в эфир в июне 2024 года. Команда журналистов европейского телеканала ARTE TV сопровождала трех наших пациентов с синдромом длительного ковида и поствакцинальным синдромом и взяла интервью у них и у нашей команды в Центре афереза. Здесь вы можете посмотреть отрывок из документального фильма, который также легко смотреть пациентам с когнитивными нарушениями, туманом в мозгу и связанными с ним мигренями. Английская озвучка от Dubly.
С тех пор как был снят этот документальный фильм, были сделаны новые научные выводы, с последними опубликованными исследованиями вы можете ознакомиться здесь.
Маркус опубликовал статью в своем блоге здесьгде он описывает события и обновления, произошедшие после съемок документального фильма.

